Abstracts (first author)

Talk 

Effect of Phages on the Cost of Antibiotic Resistance

Author(s): Hall A, Angst D

Summary:

Experimental studies of antibiotic resistance evolution typically employ a single bacterial species in pure culture. However, outside the laboratory, parasitism of bacteria by viruses (phages) is ubiquitous. I used experimental populations of Escherichia coli to show that phage parasitism altered the outcomes of competitions between antibiotic-resistant and sensitive genotypes. Phages caused rapid selective sweeps, associated with the emergence of phage-resistant mutants, and this was approximately equally likely to favour antibiotic-resistant or sensitive genotypes when their initial frequencies were similar. An elevated mutation rate was advantageous in the presence of phages, suggesting that a given antibiotic-resistant or sensitive genotype is more likely to fix under phage parasitism when it has a high mutation supply rate relative to other genotypes. Given their abundance in nature, phages probably modify selection on other traits in many different scenarios.



Contacts

Chairman: Octávio S. Paulo
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Address

XIV Congress of the European Society for Evolutionary Biology

Organization Team
Department of Animal Biology (DBA)
Faculty of Sciences of the University of Lisbon
P-1749-016 Lisbon
Portugal

Website

Computational Biology & Population Genomics Group 
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