Faculty of Mathematics and Natural Sciences, University of Kiel
Department of evolutionary ecology and genetics
Am Botanischen Garten 1-9
Abstracts (first author)
Adaptation of Pseudomonas aeruginosa to different antibioticsPDF
Pseudomonas aeruginosa is a widespread Gram-negative bacterium found in water, soil, plants and animals. Its diverse array of virulence factors allows it to establish and proliferate in environments ranging from plant roots to the human respiratory tract. It plays an important role in chronic infections such as in cystic fibrosis (CF), and is the most commonly isolated nosocomial bacterium. Pseudomonads naturally possess multiple response mechanisms against antimicrobial treatments granting it resistance against the most commonly used antibiotics. They range from efflux pump systems and complex genetic regulation to intricate social behaviours like biofilm formation or swarming. However, to date, we lack detailed understanding of the relative importance of each of these mechanisms and their interplay during resistance evolution. Thus, our study uses controlled evolution experiments to evaluate in how far different resistance mechanisms are selectively favored throughout P.aeruginosa adaptation to different types of antibiotics.