Abstracts (first author)


How has the genetic architecture of key life history traits responded to the demographic transition in a human population?

Author(s): Bolund E, Lummaa V


A central issue in evolutionary biology concerns the long-term reliability of predictions of evolutionary change. Theory predicts that the genetic architecture of life history traits (summarised by the additive genetic variance-covariance matrix, G) will change over time and thus affect how traits respond to selection. However, studies have found support both for fast changes as well as for a great consistency in G over time. It thus remains unclear how rapidly and in what manner G itself changes in response to changes in selection pressures or environment.

The demographic transition to low mortality and fertility rates in many recent human populations involves a drastic environmental change, but its consequences for the evolutionary potential of traits have rarely been addressed. We use genealogical data from 8 parishes in Finland, from natural high (5-6 offspring) to recent low (< 2 offspring) fertility over 350 years to address this question at the genetic level. We study four key life history traits; age at first and last reproduction, number of offspring and longevity, all of which show significant phenotypic changes during the time period. We use the animal model quantitative genetic approach to study whether and how the genetic architecture underlying these traits has also changed, by comparing the full G matrix in the periods before and after the demographic transition.

First, we establish significant additive genetic variance and heritability for all traits during both time periods. Second, we present the genetic covariances and correlations between all four traits during both periods. Third, we compare the overall G matrix of the two periods to elucidate if and how G has changed during the demographic transition. The results provide a novel insight in how traits can respond to selection in contemporary human populations and whether the potential for such responses might have changed along with the recent demographic and societal changes.


Divergent selection on, but no genetic conflict over, female and male timing and rate of reproduction in a human population

Author(s): Bolund E, Bouwhuis S, Pettay J, Lummaa V


The sexes often have different phenotypic optima for important life-history traits and because they share much of their genome, this can lead to a conflict over trait expression. In mammals, the obligate costs of reproduction are higher for females, making reproductive timing and rate especially liable to conflict between the sexes. While studies from wild vertebrate populations show support for such sexual conflict, it remains unexplored in humans. We used a pedigreed human population from pre-industrial Finland to estimate sexual conflict over age at first and last reproduction, reproductive lifespan and reproductive rate. We found that the phenotypic selection gradients differed between the sexes. For age at first and last reproduction and reproductive lifespan, the relationships with fitness (number of grandchildren) tended to be nonlinear in women, suggesting an intermediate optimum value, while they were linear in men. Both sexes showed a linear decrease in fitness with increasing reproductive rate. We next established significant heritabilities in both sexes for all traits. All traits, except reproductive rate, showed strongly positive intersexual genetic correlations and were strongly genetically correlated with fitness in both sexes. Moreover, the genetic correlations with fitness were almost identical in men and women. For reproductive rate, the intersexual correlation and the correlation with fitness were weaker but again similar between the sexes. These findings illustrate that apparent sexual conflict at the phenotypic level is not necessarily indicative of an underlying genetic conflict and further emphasize the need for incorporating a genetic perspective into studies of human life-history evolution.

Abstracts (coauthor)

Fewer invited talks by women in evolutionary biology: men accept invitations to speak more often than women

Author(s): Dugdale, HL, Schroeder J, Radersma R, Hinsch M, Buehler DM, Saul J, Porter L, Liker A, De Cauwer I, Johnson PJ, Santure AW, Griffin AS, Bolund E, Ross L, Webb TJ, Feulner PGD, Winney I, Szulkin M, Komdeur J, Versteegh MA, Hemelrijk CK, Svensson EI, Edwards H, Karlsson M, West SA, Barrett ELB, Richardson DS, Van den Brink V, Wimpenny JH, Ellwood SA, Rees M, Matson KD, Charmantier A, Dos Remedios N, Schneider NA, Teplitsky C, Laurance WF, Butlin RK, Horrocks NP


Lower ‘visibility’ of female scientists, compared to male scientists, is a potential reason for the under-representation of women among senior academic ranks. Visibility in the scientific community stems partly from presenting research as an invited speaker at organised meetings. We analysed the sex ratio of presenters at the European Society for Evolutionary Biology Congress 2011, where all abstract submissions were accepted for presentation. Women were under-represented among invited speakers at symposia (15% women) compared to all presenters (46%), regular oral presenters (41%) and plenary speakers (25%). At the ESEB congresses in 2001–2011, 8–23% of invited speakers were women. This under-representation of women is partly attributable to a larger proportion of women, than men, declining invitations: in 2011, 50% of women declined an invitation to speak compared to 26% of men. We expect invited speakers to be senior scientists or authors of recent papers in high-impact journals. Considering all invited speakers (including declined invitations), 23% were women. This was lower than the baseline sex ratios of early–mid career stage scientists, but was similar to senior scientists and authors published in high-impact journals. High-quality science by women therefore has low exposure at international meetings, which will constrain Evolutionary Biology from reaching its full potential. We wish to highlight the wider implications of turning down invitations to speak. In particular, under-representation of women among invited speakers reduces the number of female role models for evolutionary biology students and contributes to the leaky pipeline. We encourage conference organisers to implement steps to increase acceptance rates of invited talks.


Chairman: Octávio S. Paulo
Tel: 00 351 217500614 direct
Tel: 00 351 217500000 ext22359
Fax: 00 351 217500028
email: mail@eseb2013.com


XIV Congress of the European Society for Evolutionary Biology

Organization Team
Department of Animal Biology (DBA)
Faculty of Sciences of the University of Lisbon
P-1749-016 Lisbon


Computational Biology & Population Genomics Group