Abstracts (first author)

Talk 

Examining the link between genotype and phentype: mitochondrial gene expression levels across distinct haplotypes, sexes, and ages

Author(s): Camus F, Wolf JBW, Morrow EH, Dowling DK

Summary:

Mitochondria are key components of cellular metabolic processing, providing most of the cellular energy required for survival. The small set of genes located within the mitochondria has recently been the subject of much attention by evolutionary biologists, as a groundswell of studies have documented that allelic variance within the mitochondrial DNA (mtDNA) often confers modifications to the phenotype. Mitochondria have been shown to play an active role in the process of ageing, as already proposed by Harman in 1972, and recent studies suggest that some of this allelic variance is even male-specific. Here we use the fruitfly Drosophila melanogaster as a model to advance our understanding of the link between the mitochondrial genotype and phenotype. We sequenced full mitochondrial genomes 13 lines and examine genotype-specific transcriptional profiles of 10 (out of 13) mitochondrial key genes on an isogenic nuclear background. Gene expression patterns are specifically examined for males and females and across age classes. Our goal is to understand the elusive mechanisms that mediate mitochondrially-encoded effects on the phenotype, and to home in on the candidate mutations that cause these effects.


Video


Contacts

Chairman: Octávio S. Paulo
Tel: 00 351 217500614 direct
Tel: 00 351 217500000 ext22359
Fax: 00 351 217500028
email: mail@eseb2013.com

Address

XIV Congress of the European Society for Evolutionary Biology

Organization Team
Department of Animal Biology (DBA)
Faculty of Sciences of the University of Lisbon
P-1749-016 Lisbon
Portugal

Website

Computational Biology & Population Genomics Group 
Close