Abstracts (first author)

Poster 

Relating the outcome of Hepatitis C virus (HCV) infection with different host SNP polymorphisms in a HCV-Human Inmunodeficiency-1 virus (HIV) coinfected Majorcan population treated with pegylated interferon plus Ribavirin (pegIFN+RBV).

Author(s): Castro JA, Matas M, Cifuentes C, Payeras A, Homar F, González-Candelas F, López-Labrador F, Moya A, Picornell A, Ramon C

Summary:

HCV infection is one of the main causes of chronic hepatitis, cirrhosis and hepatocellular carcinoma. The HCV-related disease is accelerated in HIV-coinfected individuals. In these patients, the response to antiviral treatment depends on viral and host factors. Among host factors, several genetic polymorphisms (SNPs) have been associated with treatment response. In the present study, we correlated different host SNPs in the IL28b, CTLA4, LDLr, and HFE genes together with mtDNA haplogroups with the outcome of HCV infection and the response to pegIFN-RBV treatment in a Majorcan cohort with HCV-HIV coinfection. We selected sixty-three HCV-HIV coinfected patients and 59 anonymous non-infected controls. Whereas the population frequency of IL28b alleles was similar to that found in other European-American cohort, the frequency of the rs12979860 C allele was lower compared to other Spanish cohorts. The frequencies of CTLA4 and LDLr polymorphisms were similar to those found in other populations. Differences between patient and control cohorts were found for the H63D mutation of the HFE gene. There were no other differences between patients and controls, regarding the frequencies of other polymorphisms or mitochondrial haplogroups. In the HCV/HIV cohort, the most significant data was found in pegIFN-RBV treatment at 4 weeks, where the IL28b rs12979860 (CC) genotype was significantly associated with rapid virologic response, whereas spontaneous clearance was higher in patients with the CTLA4 +49G allele. No significant relationship was found between SNPs in the LDLr, HFE, nor mtDNA haplogroups with response to treatment. In summary, our results highlight the importance of the genetic background of the host on response to therapy in this special cohort.



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Address

XIV Congress of the European Society for Evolutionary Biology

Organization Team
Department of Animal Biology (DBA)
Faculty of Sciences of the University of Lisbon
P-1749-016 Lisbon
Portugal

Website

Computational Biology & Population Genomics Group 
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