Abstracts (first author)

Talk 

A genome-wide scan for relaxation of constraints in the human lineage affecting specific functional processes

Author(s): Somel M, Wilson-Sayres M, Jordan G, Huerta-Sanchez E, Fumagalli M, Ferrer-Admetlla A, Nielsen R

Summary:

Changes in the subsistence mode of a species can lead to adaptive evolution of new functions, while it can also cause relaxed negative selection in previously essential functions. While positive selection in humans has been intensely studied, functional processes subject to relaxed constraints in the human lineage remain largely unknown. Here we present a framework for detecting relaxation of selective constraints that affect a particular functional process specifically in one taxon. Jointly using human and chimpanzee population genomic data with mammalian comparative genomic data, we identify olfactory receptors and proteasome subunits as candidates of relaxed constraints in humans: both gene sets contain high frequency non-synonymous mutations in humans while having conserved amino-acid sequences across other mammals. We further discuss the possible underlying causes of this signal.


Video


Contacts

Chairman: Octávio S. Paulo
Tel: 00 351 217500614 direct
Tel: 00 351 217500000 ext22359
Fax: 00 351 217500028
email: mail@eseb2013.com

Address

XIV Congress of the European Society for Evolutionary Biology

Organization Team
Department of Animal Biology (DBA)
Faculty of Sciences of the University of Lisbon
P-1749-016 Lisbon
Portugal

Website

Computational Biology & Population Genomics Group 
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