Abstracts (first author)
Determinants of protein evolutionary rates in light of ENCODE functional genomics
The aim is to understand how the complex anatomy and developmental processes of animal influence the evolution of protein-coding genes.
The influence of different parameters, from gene size to expression levels, on the evolution of proteins has been previously studied in yeast, Drosophila and mammals. Here we investigate these relations further, especially taking in account gene expression and chromatin organization in different organs and different developmental stages. For expression we used a microarray experiment over zebrafish development as well as the RNA-seq data from ENCODE for 22 different tissues of mouse. We also used chromatin accessibility in mouse tissues, and we use ENCODE data to define which transcript is used as reference to compute gene length, intron number, etc. We find strong differences between tissues or developmental stages in impact of expression on evolutionary rate. Over all tissues, an interesting result is that evolutionary rate is better correlated with maximal expression in one tissue then with average expression value over all tissues.